{
  "title": "Liraglutide (public encyclopedia provenance reconstruction)",
  "therapyArea": "Metabolic",
  "finding": "Reconstructed from 20 public encyclopedia revisions showing article evolution",
  "provenance": {
    "sourceArtifacts": [
      {
        "artifactId": "wp-revision-192122871",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192122871)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192122871",
        "version": "192122871",
        "publicationDate": "",
        "effectiveDate": "",
        "retrievalUrl": "",
        "summary": "Article revision 192122871",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192123901",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192123901)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192123901",
        "version": "192123901",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192123901",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192127740",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192127740)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192127740",
        "version": "192127740",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192127740",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192131328",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192131328)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192131328",
        "version": "192131328",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192131328",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192132071",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192132071)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192132071",
        "version": "192132071",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192132071",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192132994",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192132994)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192132994",
        "version": "192132994",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192132994",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192133935",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192133935)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192133935",
        "version": "192133935",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192133935",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192134504",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192134504)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192134504",
        "version": "192134504",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192134504",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192135498",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192135498)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192135498",
        "version": "192135498",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192135498",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192138024",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192138024)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192138024",
        "version": "192138024",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192138024",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192138737",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192138737)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192138737",
        "version": "192138737",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192138737",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192139472",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192139472)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192139472",
        "version": "192139472",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192139472",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192140127",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192140127)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192140127",
        "version": "192140127",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192140127",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192141705",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192141705)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192141705",
        "version": "192141705",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192141705",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192142022",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192142022)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192142022",
        "version": "192142022",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192142022",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192142806",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192142806)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192142806",
        "version": "192142806",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192142806",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192142942",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192142942)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192142942",
        "version": "192142942",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192142942",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192143244",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192143244)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192143244",
        "version": "192143244",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192143244",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192143776",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192143776)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192143776",
        "version": "192143776",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192143776",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      },
      {
        "artifactId": "wp-revision-192145258",
        "artifactType": "other",
        "issuer": "Wikipedia",
        "title": "Liraglutide (revision 192145258)",
        "stableIdentifier": "https://en.wikipedia.org/w/index.php?title=Liraglutide&oldid=192145258",
        "version": "192145258",
        "publicationDate": "2008-02-17",
        "effectiveDate": "2008-02-17",
        "retrievalUrl": "",
        "summary": "Article revision 192145258",
        "contentHash": "",
        "ingestedAt": "2026-06-19",
        "epistemicStatus": "directly-observed"
      }
    ],
    "sourceAssertions": [
      {
        "assertionId": "assert-following-subcutaneous-administration-the-protracted-action-",
        "artifactId": "wp-revision-192123901",
        "exactText": "Following subcutaneous administration, the protracted action profile is based on three mechanisms: binding to albumin and enzymatic stability towards the DPP-IV enzyme both of which result in a long plasma half-life, and self-association which results in a slow absorption",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-liraglutide-action-is-mediated-via-a-specific-interaction-wi",
        "artifactId": "wp-revision-192123901",
        "exactText": "Liraglutide action is mediated via a specific interaction with GLP-1 receptors, leading to an increase in cAMP",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-liraglutide-stimulates-insulin-secretion-and-improves-beta-c",
        "artifactId": "wp-revision-192123901",
        "exactText": "Liraglutide stimulates insulin secretion and improves beta-cell function in a glucose-dependent manner",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-simultaneously-liraglutide-lowers-inappropriately-high-gluca",
        "artifactId": "wp-revision-192123901",
        "exactText": "Simultaneously, liraglutide lowers inappropriately high glucagon secretion, also in a glucose dependent manner",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-thus-when-blood-glucose-is-high-insulin-secretion-is-stimula",
        "artifactId": "wp-revision-192123901",
        "exactText": "Thus, when blood glucose is high, insulin secretion is stimulated and glucagon secretion is inhibited",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-liraglutide-does-not-impair-glucagon-response-during-hypogly",
        "artifactId": "wp-revision-192123901",
        "exactText": "Liraglutide does not impair glucagon response during hypoglycaemia",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-furthermore-the-mechanism-of-blood-glucose-lowering-involves",
        "artifactId": "wp-revision-192123901",
        "exactText": "Furthermore, the mechanism of blood glucose lowering involves a minor decrease in gastric emptying",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-liraglutide-reduces-body-weight-and-body-fat-mass-by-a-mecha",
        "artifactId": "wp-revision-192123901",
        "exactText": "Liraglutide reduces body weight and body fat mass, by a mechanism of reduced hunger and lowered energy intake",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-liraglutide-has-been-shown-to-delay-the-progression-of-diabe",
        "artifactId": "wp-revision-192123901",
        "exactText": "Liraglutide has been shown to delay the progression of diabetes in animal models of pre-diabetes",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-liraglutide-has-been-shown-in-vitro-to-be-a-potent-agent-for",
        "artifactId": "wp-revision-192123901",
        "exactText": "Liraglutide has been shown in vitro to be a potent agent for specific stimulation of beta-cell proliferation and prevention of both cytokine and free fatty acid induced apoptosis",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-in-vivo-liraglutide-increases-insulin-biosynthesis-and-beta-",
        "artifactId": "wp-revision-192123901",
        "exactText": "In vivo, liraglutide increases insulin biosynthesis, and beta-cell mass in diabetic animal models",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-references-http-www-glucagon-com-liraglutide-htm",
        "artifactId": "wp-revision-192131328",
        "exactText": "References:\n[http://www.glucagon.com/liraglutide.htm]",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-drucker-lab-http-www-glucagon-com-liraglutide-htm",
        "artifactId": "wp-revision-192132071",
        "exactText": "Drucker Lab [http://www.glucagon.com/liraglutide.htm]",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-in-a-phase-2-trial-enrolling-165-patients-with-type-2-diabet",
        "artifactId": "wp-revision-192133935",
        "exactText": "In a phase 2 trial enrolling 165 patients with type 2 diabetes, 14 weeks of liraglutide monotherapy reduced the estimated mean HbA1c values by 1.74% vs placebo from an average baseline of 8.5% and FPG by 3.4 mmol/l without hypoglycemic episodes",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-a-dose-dependent-decrease-in-body-weight-was-observed-with-a",
        "artifactId": "wp-revision-192133935",
        "exactText": "A dose-dependent decrease in body weight was observed, with a mean weight loss of 3.0 kg in the 1.9-mg liraglutide group",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-significant-improvements-in-indices-of-beta-cell-function-an",
        "artifactId": "wp-revision-192133935",
        "exactText": "Significant improvements in indices of beta cell function and blood pressure were also found along with a decrease in fasting glucagon with lira 1.9 mg",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-the-lead-programme-evaluated-the-efficacy-and-safety-of-lira",
        "artifactId": "wp-revision-192138024",
        "exactText": "The LEAD programme evaluated the efficacy and safety of liraglutide in patients with type 2 diabetes either as monotherapy (LEAD 3) or in combination with metformin (LEAD 2), glimepiride (LEAD 1), metformin and rosiglitazone (LEAD 4) or metformin and glimepiride (LEAD 5)",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-liraglutide-treatment-resulted-in-around-40-50-of-patients-r",
        "artifactId": "wp-revision-192138024",
        "exactText": "Liraglutide treatment resulted in around 40-50% of patients reaching the American Diabetes Association goal of HbA1c < 7% at study completion",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-however-among-the-patients-that-were-previously-treated-with",
        "artifactId": "wp-revision-192138024",
        "exactText": "However, among the patients that were previously treated with only a single oral antidiabetic drug, liraglutide treatment resulted in around 50-60% of patients reaching this goal",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-these-success-rates-were-the-result-of-an-hba1c-reduction-of",
        "artifactId": "wp-revision-192138024",
        "exactText": "These success rates were the result of an HbA1c reduction of approximately 1 to 1.5 percentage points",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-hba1c-was-sustained-for-up-to-12-months-of-liraglutide-thera",
        "artifactId": "wp-revision-192138024",
        "exactText": "HbA1c was sustained for up to 12 months of liraglutide therapy",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-the-hba1c-reduction-achieved-in-the-liraglutide-group-was-mo",
        "artifactId": "wp-revision-192138024",
        "exactText": "The HbA1c reduction achieved in the liraglutide group was more than 0.2 percentage points better than in the insulin glargine group, a difference which is statistically significant",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
      {
        "assertionId": "assert-furthermore-a-significant-improvement-in-systolic-blood-pres",
        "artifactId": "wp-revision-192138024",
        "exactText": "Furthermore, a significant improvement in systolic blood pressure and a reduction of body weight of between 3 and 4 kg were seen in patients treated with liraglutide when compared to patients treated with glimepiride",
        "location": {
          "section": "(lead)"
        },
        "extractionMethod": "automated",
        "extractionConfidence": "high",
        "extractedAt": "2008-02-17",
        "epistemicStatus": "extracted"
      },
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        "rationale": "FDA approval operationalizes the claim that liraglutide stimulates insulin secretion and improves glycemic control in type 2 diabetes."
      },
      {
        "epistemicStatus": "institution-confirmed",
        "commitmentId": "rely-fda-liraglutide-obesity",
        "claimVariantId": "var-fam-sentence-7-1",
        "commitmentType": "operational-use",
        "committingInstitution": "FDA",
        "sourceArtifact": {
          "artifactType": "regulatory",
          "issuer": "U.S. Food and Drug Administration",
          "title": "Liraglutide (Saxenda) approval for chronic weight management, NDA 206321",
          "stableIdentifier": "https://www.accessdata.fda.gov/drugsatfda_docs/applets/2014/206321Orig1s000TOC.cfm"
        },
        "commitmentDate": "2014-12-23",
        "confidence": "high",
        "rationale": "FDA approval for chronic weight management operationalizes the claim that liraglutide reduces body weight and fat mass."
      },
      {
        "epistemicStatus": "inferred",
        "commitmentId": "rely-ada-liraglutide-ascvd",
        "claimVariantId": "var-fam-sentence-3-1",
        "commitmentType": "endorsement",
        "committingInstitution": "American Diabetes Association",
        "sourceArtifact": {
          "artifactType": "guideline",
          "issuer": "American Diabetes Association",
          "title": "Standards of Care in Diabetes — Glycemic Goals",
          "stableIdentifier": "https://diabetesjournals.org/care/issue/47/Supplement_1"
        },
        "commitmentDate": "2024-01-01",
        "confidence": "medium",
        "rationale": "ADA Standards of Care endorse liraglutide and other GLP-1 receptor agonists for type 2 diabetes, particularly when ASCVD is present."
      }
    ],
    "observedEvents": [
      {
        "eventId": "evt-fda-liraglutide-t2d",
        "eventType": "artifact-issued",
        "title": "FDA approves liraglutide for type 2 diabetes",
        "description": "FDA approves liraglutide (Victoza) for improving glycemic control in adults with type 2 diabetes.",
        "occurredAt": "2010-01-25",
        "jurisdiction": "United States",
        "epistemicStatus": "directly-observed"
      },
      {
        "eventId": "evt-fda-liraglutide-obesity",
        "eventType": "artifact-issued",
        "title": "FDA approves liraglutide for chronic weight management",
        "description": "FDA approves liraglutide (Saxenda) for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity.",
        "occurredAt": "2014-12-23",
        "jurisdiction": "United States",
        "epistemicStatus": "directly-observed"
      },
      {
        "eventId": "evt-ada-liraglutide-endorsement",
        "eventType": "guideline-updated",
        "title": "ADA Standards of Care endorse liraglutide class",
        "description": "American Diabetes Association Standards of Care recommend liraglutide and other GLP-1 receptor agonists for type 2 diabetes with ASCVD.",
        "occurredAt": "2024-01-01",
        "jurisdiction": "United States",
        "epistemicStatus": "directly-observed"
      }
    ],
    "eventImpacts": [
      {
        "impactId": "impact-fam-sentence-1-modification",
        "claimFamilyId": "fam-sentence-1",
        "eventId": "",
        "impactType": "support-enhanced",
        "confidence": "medium",
        "evidentiaryBasis": [
          "assert-following-subcutaneous-administration-the-protracted-action-",
          "assert-following-subcutaneous-administration-the-protracted-action-"
        ],
        "analysisDescription": "2 variants detected across revision history",
        "epistemicStatus": "inferred"
      },
      {
        "impactId": "impact-fam-sentence-3-modification",
        "claimFamilyId": "fam-sentence-3",
        "eventId": "",
        "impactType": "support-enhanced",
        "confidence": "medium",
        "evidentiaryBasis": [
          "assert-liraglutide-stimulates-insulin-secretion-and-improves-beta-c",
          "assert-simultaneously-liraglutide-lowers-inappropriately-high-gluca",
          "assert-liraglutide-stimulates-insulin-secretion-and-improves-beta-c"
        ],
        "analysisDescription": "3 variants detected across revision history",
        "epistemicStatus": "inferred"
      },
      {
        "impactId": "impact-fam-sentence-8-modification",
        "claimFamilyId": "fam-sentence-8",
        "eventId": "",
        "impactType": "support-enhanced",
        "confidence": "medium",
        "evidentiaryBasis": [
          "assert-liraglutide-has-been-shown-to-delay-the-progression-of-diabe",
          "assert-liraglutide-has-been-shown-to-delay-the-progression-of-diabe"
        ],
        "analysisDescription": "2 variants detected across revision history",
        "epistemicStatus": "inferred"
      },
      {
        "impactId": "impact-fam-sentence-11-modification",
        "claimFamilyId": "fam-sentence-11",
        "eventId": "",
        "impactType": "support-enhanced",
        "confidence": "medium",
        "evidentiaryBasis": [
          "assert-references-http-www-glucagon-com-liraglutide-htm",
          "assert-drucker-lab-http-www-glucagon-com-liraglutide-htm",
          "assert-drucker-lab-http-www-glucagon-com-liraglutide-htm-novo-nordi"
        ],
        "analysisDescription": "3 variants detected across revision history",
        "epistemicStatus": "inferred"
      },
      {
        "impactId": "impact-fam-sentence-12-modification",
        "claimFamilyId": "fam-sentence-12",
        "eventId": "",
        "impactType": "support-enhanced",
        "confidence": "medium",
        "evidentiaryBasis": [
          "assert-in-a-phase-2-trial-enrolling-165-patients-with-type-2-diabet",
          "assert-in-a-phase-2-trial-enrolling-165-patients-with-type-2-diabet",
          "assert-in-a-phase-2-trial-enrolling-165-patients-with-type-2-diabet"
        ],
        "analysisDescription": "3 variants detected across revision history",
        "epistemicStatus": "inferred"
      },
      {
        "impactId": "impact-fam-sentence-14-modification",
        "claimFamilyId": "fam-sentence-14",
        "eventId": "",
        "impactType": "support-enhanced",
        "confidence": "medium",
        "evidentiaryBasis": [
          "assert-significant-improvements-in-indices-of-beta-cell-function-an",
          "assert-significant-improvements-in-indices-of-beta-cell-function-an",
          "assert-furthermore-a-significant-improvement-in-systolic-blood-pres"
        ],
        "analysisDescription": "3 variants detected across revision history",
        "epistemicStatus": "inferred"
      },
      {
        "impactId": "impact-fam-sentence-16-modification",
        "claimFamilyId": "fam-sentence-16",
        "eventId": "",
        "impactType": "support-enhanced",
        "confidence": "medium",
        "evidentiaryBasis": [
          "assert-liraglutide-treatment-resulted-in-around-40-50-of-patients-r",
          "assert-however-among-the-patients-that-were-previously-treated-with",
          "assert-liraglutide-treatment-resulted-in-around-40-50-of-patients-r",
          "assert-liraglutide-treatment-resulted-in-around-40-50-of-patients-r"
        ],
        "analysisDescription": "4 variants detected across revision history",
        "epistemicStatus": "inferred"
      },
      {
        "impactId": "impact-fam-sentence-22-modification",
        "claimFamilyId": "fam-sentence-22",
        "eventId": "",
        "impactType": "support-enhanced",
        "confidence": "medium",
        "evidentiaryBasis": [
          "assert-the-glp-1-receptor-is-the-target-for-native-glp-1-an-endogen",
          "assert-the-glp-1-receptor-is-the-target-for-native-glp-1-an-endogen"
        ],
        "analysisDescription": "2 variants detected across revision history",
        "epistemicStatus": "inferred"
      },
      {
        "epistemicStatus": "inferred",
        "impactId": "impact-fda-liraglutide-t2d-fam-3",
        "claimFamilyId": "fam-sentence-3",
        "eventId": "evt-fda-liraglutide-t2d",
        "impactType": "support-enhanced",
        "confidence": "high",
        "evidentiaryBasis": [
          "rely-fda-liraglutide-t2d"
        ],
        "analysisDescription": "FDA approval strengthens the claim that liraglutide stimulates insulin secretion and improves beta-cell function in T2D."
      },
      {
        "epistemicStatus": "inferred",
        "impactId": "impact-fda-liraglutide-obesity-fam-7",
        "claimFamilyId": "fam-sentence-7",
        "eventId": "evt-fda-liraglutide-obesity",
        "impactType": "support-enhanced",
        "confidence": "high",
        "evidentiaryBasis": [
          "rely-fda-liraglutide-obesity"
        ],
        "analysisDescription": "FDA approval for chronic weight management supports the claim that liraglutide reduces body weight and fat mass."
      },
      {
        "epistemicStatus": "inferred",
        "impactId": "impact-ada-liraglutide-fam-3",
        "claimFamilyId": "fam-sentence-3",
        "eventId": "evt-ada-liraglutide-endorsement",
        "impactType": "support-enhanced",
        "confidence": "medium",
        "evidentiaryBasis": [
          "rely-ada-liraglutide-ascvd"
        ],
        "analysisDescription": "ADA endorsement adds guideline support to the T2D claim, with ASCVD qualification."
      }
    ],
    "reviewDecisions": [
      {
        "epistemicStatus": "analyst-asserted",
        "decisionId": "decision-fda-liraglutide-t2d-adopt",
        "claimFamilyId": "fam-sentence-3",
        "eventId": "evt-fda-liraglutide-t2d",
        "decisionType": "adopt",
        "rationale": "FDA approval provides direct operationalization for the T2D mechanism claim.",
        "inputs": [
          "impact-fda-liraglutide-t2d-fam-3",
          "rely-fda-liraglutide-t2d"
        ],
        "decidedAt": "2010-01-25",
        "decidedBy": "automated reviewer",
        "confident": true
      },
      {
        "epistemicStatus": "analyst-asserted",
        "decisionId": "decision-fda-liraglutide-obesity-narrow",
        "claimFamilyId": "fam-sentence-7",
        "eventId": "evt-fda-liraglutide-obesity",
        "decisionType": "amend",
        "rationale": "FDA obesity approval narrows the weight-loss claim from observational to approved indication without changing the family scope.",
        "inputs": [
          "impact-fda-liraglutide-obesity-fam-7",
          "rely-fda-liraglutide-obesity"
        ],
        "decidedAt": "2014-12-23",
        "decidedBy": "automated reviewer",
        "confident": true
      },
      {
        "epistemicStatus": "analyst-asserted",
        "decisionId": "decision-ada-liraglutide-retain",
        "claimFamilyId": "fam-sentence-3",
        "eventId": "evt-ada-liraglutide-endorsement",
        "decisionType": "retain-with-caveats",
        "rationale": "ADA endorsement supports the claim but is inferred from guideline language; retain with ASCVD qualification.",
        "inputs": [
          "impact-ada-liraglutide-fam-3",
          "rely-ada-liraglutide-ascvd"
        ],
        "decidedAt": "2024-01-01",
        "decidedBy": "automated reviewer",
        "confident": false
      }
    ],
    "assessments": [
      {
        "familyId": "fam-sentence-1",
        "direction": "stable",
        "confidence": "low",
        "variantCount": 2,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "2 variants, qualifies",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-2",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-3",
        "direction": "stable",
        "confidence": "low",
        "variantCount": 3,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "3 variants, qualifies, qualifies",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-4",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-5",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-6",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-7",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-8",
        "direction": "stable",
        "confidence": "low",
        "variantCount": 2,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "2 variants, qualifies",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-9",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-10",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-11",
        "direction": "stable",
        "confidence": "low",
        "variantCount": 3,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "3 variants, qualifies, qualifies",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-12",
        "direction": "stable",
        "confidence": "low",
        "variantCount": 3,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "3 variants, qualifies, qualifies",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-13",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-14",
        "direction": "stable",
        "confidence": "low",
        "variantCount": 3,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "3 variants, qualifies, qualifies",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-15",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-16",
        "direction": "stable",
        "confidence": "low",
        "variantCount": 4,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "4 variants, qualifies, qualifies, qualifies",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-17",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-18",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-19",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-20",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-21",
        "direction": "stable",
        "confidence": "medium",
        "variantCount": 1,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "1 variants, no relationships",
        "epistemicStatus": "analyst-asserted"
      },
      {
        "familyId": "fam-sentence-22",
        "direction": "stable",
        "confidence": "low",
        "variantCount": 2,
        "netDirection": 0,
        "disputeCount": 0,
        "lastChangeAt": "2008-02-17",
        "summary": "2 variants, qualifies",
        "epistemicStatus": "analyst-asserted"
      }
    ]
  },
  "classification": {
    "evidentiaryFields": [
      "Public encyclopedia version identifiers",
      "Edit timestamps",
      "Editor usernames",
      "Edit comments",
      "Citation URLs",
      "Page move records",
      "Template changes"
    ],
    "derivedFields": [
      "Sentence-level diffs (before/after)",
      "Citation added/removed events",
      "Section reorganization events",
      "Edit magnitude (minor/moderate/major)",
      "Content change type",
      "Key terms extraction",
      "Direction signal (strengthening/weakening/neutral)"
    ],
    "inferredFields": [
      "Claim family membership",
      "Claim variant relationships",
      "Confidence assignment",
      "Impact direction",
      "Decision rationale reconstruction",
      "Reliance commitment interpretation"
    ],
    "illustrativeFields": []
  },
  "reproducibility": {
    "analysts": 1,
    "method": "Single-analyst automated reconstruction. Two-analyst reproducibility validation has not yet been performed on this specimen.",
    "familyOverlap": {
      "matched": 0,
      "total": 0,
      "ratio": 0
    },
    "variantOverlap": {
      "matched": 0,
      "total": 0,
      "ratio": 0
    },
    "documentedDisagreements": [],
    "passed": false
  },
  "crossSpecimenImpacts": [
    {
      "impactId": "cross-liraglutide-glp1-obesity",
      "direction": "outgoing",
      "targetSpecimenRoute": "/baselines/provenance/glp1/",
      "targetSpecimenTitle": "GLP-1 receptor agonist (public encyclopedia provenance reconstruction)",
      "targetClaimFamilyId": "fam-sentence-2",
      "sourceEventId": "evt-fda-liraglutide-obesity",
      "impactType": "scope-broadened",
      "confidence": "high",
      "rationale": "FDA approval of liraglutide for chronic weight management broadens the GLP-1 class claim about licensed indications, adding obesity/weight-management to the class narrative.",
      "sourceEventTitle": "FDA approves liraglutide for chronic weight management"
    },
    {
      "impactId": "cross-liraglutide-glp1-t2d",
      "direction": "incoming",
      "targetSpecimenRoute": "/baselines/provenance/glp1/",
      "targetSpecimenTitle": "GLP-1 receptor agonist (public encyclopedia provenance reconstruction)",
      "targetClaimFamilyId": "fam-sentence-3",
      "sourceEventId": "evt-ada-liraglutide-endorsement",
      "impactType": "support-enhanced",
      "confidence": "medium",
      "rationale": "The GLP-1 class ADA endorsement inferred in the GLP-1 specimen also supports liraglutide's T2D claim, demonstrating how class-level institutional reliance propagates to member drugs.",
      "sourceEventTitle": "ADA Standards of Care endorse liraglutide class"
    }
  ]
}