GLP-1 receptor agonist claim history: diabetes to obesity indication
Provenance reconstruction of a metabolic claim from a public encyclopedia revision history, validated by two independent analysts.
That is the premise, and the research program tests it: estimates for named regulatory, guideline, and coverage decisions, registered before the outcome is known and then checked against what happened. The method is public so the answer does not depend on trusting us. The registry stands whichever way the answer comes out; About separates what is contributed now from what is under test.
Registry snapshot: . Several records concern the same asset, with overlapping outcomes.
One cell for each registered forecast; open one to read its record. A cell fills in when its forecast resolves, whichever way it came out. A forecast that could not be scored stays in its class count as a hatched cell.
Registration fixes what was estimated and when. Each forecast is scored once its deadline passes and the outcome is adjudicated, against the three baselines registered beside it.
Can defined public medical transitions be forecast prospectively?
in progressDo the numbers mean what they say? Does a 70% forecast happen about 70 times in 100?
plannedDoes NextConsensus outperform base-rate, heuristic, expert, and LLM baselines?
plannedWhich evidence and institutional features improve forecasts?
plannedDoes an action by one authority make an action by another more likely, including across markets?
plannedWhich authorities move first, and which follow?
plannedHow far ahead can a forecast be issued before its false alarms cost more than the lead time is worth?
plannedWhich target rungs are forecastable, and which are not?
plannedHow many resolved forecasts does one kind of decision need before its record means anything?
plannedEvidence, expert recognition, and the decision itself move at different speeds. A decision at rungs 5–7 of the 12-rung ladder is one of three public actions: a guideline body changing a recommendation, a regulator changing a label, a payer changing coverage. The model estimates the probability of one of those happening by a stated deadline, from what was observable at registration.
An observable upstream event enters the time-bounded evidence record.
Public research tests whether the method forecasts. Program work tests whether a forecast is useful in a decision. Neither result stands in for the other.
Reconstruct forecasts from historical evidence. Hold out future information. Score against outcomes. Control for temporal leakage.
Register forecasts before outcomes are known. Freeze the evidence state. Publish registration timestamps. Adjudicate outcomes independently.
Compute Brier scores, reliability curves, and baseline comparisons per cohort, event class, and method version.
Identify which target rungs can be forecast. Report verdicts: detection, nowcasting, forecasting, or unsupported.
Between reconstruction and forecasting sits a step that ranks which claims to look at first, by how much their evidence has moved. It exists as a review workflow; the validation below decides whether it becomes a program.
The direction and strength of movement on rungs 1–4 (support attaching, qualifiers falling away, spread across sources, or regulator language arriving early), ordered into a review queue with the record and its limits.
Whether the queue ranks claims that later moved on rungs 5–7 higher than those that did not, measured on held-out history with the cutoff enforced. An earlier proof cycle that appeared to show this was invalid; the corrected rebuild found no lift in general revision activity, so the test now runs on specific claims and specific patterns.
Two reconstructions built to test the method, not an asset: whether one claim can be held across years of public edits, and whether a second analyst working independently arrives at the same claim families. Both use a public encyclopedia's revision history, the largest openly versioned medical text available.
Provenance reconstruction of a metabolic claim from a public encyclopedia revision history, validated by two independent analysts.
Provenance reconstruction of a single-drug metabolic article, showing how a dated source trail can be preserved beyond the GLP-1 class example.
Method basis
The works this program leans on. They frame the problem — evidence records age, guidelines lag, and citations make claims look more settled than they are.
Shows that review currency varies by topic and can decay before normal review schedules catch it.
Shows that guideline validity changes over time and should be reassessed against new evidence.
Background on the gap between evidence production and institutional uptake; useful as a caution, not as a fixed timing claim.
Frames evidence synthesis as an updating problem, not a one-time search problem.
Shows how citation patterns can make a claim appear more settled than the source record supports.
Documents how reporting can overstate or distract from primary results, which is one way claim wording can outrun evidence.
Shows why settled-looking practices and claims need structured review when stronger contrary evidence appears.
Separates evidence quality from the strength of recommendations and makes uncertainty explicit.
Shows why evidence assessment and final decisions should be structured separately.
Supports transparent reporting of search, selection, appraisal, synthesis, and update methods.
Shows how healthcare decision makers expect clinical and economic evidence to be organized for formulary, coverage, policy, and reimbursement review.
Frames real-world evidence around reproducibility, registration, stakeholder involvement, and decision-maker confidence.
Supports the need for durable, inspectable, reusable evidence and provenance records.
Supports interface patterns that keep uncertainty, user control, correction, and human authority visible in AI-assisted systems.